KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
36.67
Human Site:
T971
Identified Species:
57.62
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
T971
M
L
N
G
T
D
K
T
P
A
L
I
S
D
Y
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T979
M
L
N
G
T
D
K
T
P
A
L
I
S
D
Y
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
T965
M
L
N
G
T
D
K
T
P
A
L
I
S
D
Y
Dog
Lupus familis
XP_534241
2041
231068
T1389
M
L
N
G
T
D
K
T
P
A
L
I
S
D
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
T959
M
L
N
G
T
D
K
T
P
A
L
I
S
D
Y
Rat
Rattus norvegicus
P41516
1526
173202
I926
I
E
I
T
E
L
P
I
R
T
W
T
Q
T
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
T1274
M
L
N
G
T
D
K
T
P
A
L
I
S
D
Y
Chicken
Gallus gallus
O42131
1627
183228
T976
M
L
N
G
T
E
K
T
P
A
L
I
S
D
Y
Frog
Xenopus laevis
NP_001082502
1579
178601
T948
M
L
N
G
T
E
K
T
P
P
L
I
T
D
Y
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
T970
M
L
Q
G
T
D
K
T
P
P
L
I
S
D
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
Y847
W
S
T
K
I
S
N
Y
N
P
R
E
I
M
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
Q920
R
L
I
A
G
E
P
Q
K
A
L
A
P
W
Y
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
D848
R
L
V
F
P
H
H
D
D
P
L
L
S
Y
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
S873
R
R
L
L
N
G
E
S
M
V
P
M
D
P
W
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
N828
I
L
P
M
I
L
V
N
G
A
E
G
I
G
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
100
93.3
80
86.6
N.A.
0
N.A.
26.6
20
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
100
100
93.3
86.6
N.A.
0
N.A.
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
0
0
0
60
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
47
0
7
7
0
0
0
7
60
0
% D
% Glu:
0
7
0
0
7
20
7
0
0
0
7
7
0
0
0
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
60
7
7
0
0
7
0
0
7
0
7
0
% G
% His:
0
0
0
0
0
7
7
0
0
0
0
0
0
0
0
% H
% Ile:
14
0
14
0
14
0
0
7
0
0
0
60
14
0
0
% I
% Lys:
0
0
0
7
0
0
60
0
7
0
0
0
0
0
7
% K
% Leu:
0
80
7
7
0
14
0
0
0
0
74
7
0
0
0
% L
% Met:
60
0
0
7
0
0
0
0
7
0
0
7
0
7
7
% M
% Asn:
0
0
54
0
7
0
7
7
7
0
0
0
0
0
0
% N
% Pro:
0
0
7
0
7
0
14
0
60
27
7
0
7
7
0
% P
% Gln:
0
0
7
0
0
0
0
7
0
0
0
0
7
0
0
% Q
% Arg:
20
7
0
0
0
0
0
0
7
0
7
0
0
0
0
% R
% Ser:
0
7
0
0
0
7
0
7
0
0
0
0
60
0
0
% S
% Thr:
0
0
7
7
60
0
0
60
0
7
0
7
7
7
7
% T
% Val:
0
0
7
0
0
0
7
0
0
7
0
0
0
0
0
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
7
0
0
7
7
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
74
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _